Modulating stress responses by a novel chromatin-associated guide RNA derived from tRNA

Description:

This technology revolves around the discovery of CANG-RNA, a type of tRNA-derived RNA fragment, and its critical role in plant immunity. By interacting with the genome, CANG-RNA facilitates a rapid and extensive transcriptional reprogramming, enabling plants to mount a strong defense against pathogens such as Pseudomonas syringae pv. tomato. The process relies on the involvement of key proteins DCL1 and AGO2 for the biogenesis and effect of CANG-RNA, respectively.

Key Advantages:

• Enhances plant immunity against virulent pathogens through transcriptional reprogramming.
• Direct interaction with the genome to trigger defense gene induction.
• Simple delivery method of CANG-RNA can immunize plants against future infections.
• Dependent on well-characterized molecular components (DCL1 and AGO2), facilitating targeted manipulation.

Problems Solved:

• Overcoming the challenge of rapid pathogen evolution and virulence.
• Reducing the reliance on chemical pesticides for plant protection.
• Improving the durability and efficacy of plant immune responses.

Market Applications:

• Agricultural biotechnology for crop protection and enhancement.
• Development of genetically modified crops with inherent resistance to pathogens.
• Research tools for studying plant-pathogen interactions and immune responses.