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Description: This invention introduces narciclasine-2-esters, prodrugs of the natural anticancer alkaloid narciclasine, engineered to significantly improve aqueous solubility and bioavailability. The lead compound, narciclasine-2-succinate, increases water solubility by over tenfold without compromising anticancer efficacy, facilitating effective delivery...

Published: 11/13/2025 | Inventor(s): Alexander Kornienko, Ryan Rutledge

Keywords(s): Anticancer Drug Development, Pharmaceutical Chemistry

Category(s): Cancer, Chemistry