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Novel Anti-MRSA Medicinal Compound with Azo-Functionalized Heterocyclic Structure

Description: This invention introduces a novel medicinal compound based on a heterocyclic system containing azo functionality, synthesized via azo-coupling with 4-amino-benzimidazole. It demonstrates significant efficacy against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration of 12 µM, coupled with a...

Published: 11/24/2025 | Inventor(s): Alexander Kornienko, Puppala Sathish, Carson King, Riaz Hossain

Keywords(s): Antibacterial Drug Development, Pharmaceuticals

Category(s): Chemistry, Life Science

Narciclasine Water-Soluble Prodrug

Description: This invention introduces narciclasine-2-esters, prodrugs of the natural anticancer alkaloid narciclasine, engineered to significantly improve aqueous solubility and bioavailability. The lead compound, narciclasine-2-succinate, increases water solubility by over tenfold without compromising anticancer efficacy, facilitating effective delivery...

Published: 11/13/2025 | Inventor(s): Alexander Kornienko, Ryan Rutledge

Keywords(s): Anticancer Drug Development, Pharmaceutical Chemistry

Category(s): Cancer, Chemistry

Use of Nanoclays for the Removal of Non-Plasmid DNA Components from Cellular Extracts

Description: This technology introduces a groundbreaking method for purifying pDNA through the use of nanoclay particles. By adding these specially formulated nanoclays to a mixture of biomolecular materials, such as cellular extracts, key contaminants and extraneous materials can be selectively bound and removed. This process represents a significant...

Published: 11/11/2025 | Inventor(s): Lysle Lewis, Drew Sowersby

Keywords(s): Nanoclays, Non-Plasmid DNA

Category(s): Nanotechnology, Life Science, Chemistry

Sustainable Superabsorbent Hydrogel for Innovative Farming Practices

Description: The innovation focuses on fabricating hydrogels using natural gums such as guar gum, xanthan gum, locust bean gum, and Tara gum. These hydrogels are produced through a simple and quick method, leveraging the inherent properties of natural polysaccharides to form gels and viscous solutions. Guar gum, a key component, is highlighted for...

Published: 11/11/2025 | Inventor(s): Sangchul Hwang, Sujata Mandal

Keywords(s): Farming, Hydrogels

Category(s): Agriculture, Materials, Chemistry

Process for Making pure, Blended, and Coaxial Fire-resistant Nanofibers

Description: This technology involves dissolving a flame-resistant polymer in a solvent, such as acetonitrile or dimethyl sulfoxide, and combining it with a solution of a common polymer, like polyacrylonitrile, at various concentrations. Through electrospinning, these solutions are transformed into fibers with controlled diameters and orientations,...

Published: 11/11/2025 | Inventor(s): Jennifer Irvin, David Irvin

Keywords(s): Fire Resistant Fibers

Category(s): Chemistry, Materials

Sphaeropsidin derivatives to combat aggressive cancers

Description: This technology involves the synthesis of new compounds based on the sphaeropsidin A structure, aimed at improving its potency against drug-resistant cancers. Utilizing a cross-metathesis reaction, these compounds have shown significant growth inhibitory activity in various human cancer cell lines, including glioblastoma, non-small cell...

Published: 11/18/2025 | Inventor(s): Alexander Kornienko, Dino Berthold, Antonio Evidente, Sachin Wagh, Willem van Otterlo, Aude Ingels, Veronique Mathieu

Keywords(s): Apoptosis, Cancer, Drug Resistance, Natural Products, Sphaeropsidin

Category(s): Cancer, Chemistry

Architected, 3D-Wired Nickel Cathode

Description: This technology describes a microwave-assisted hydrothermal process for nucleating and growing Al-substituted alpha-Ni(OH)2 nanosheets directly onto a carbon nanofiber paper, forming a 3D electrically wired network. This innovative method utilizes mildly acidic conditions, offering a unique approach to creating cathode materials for Ni/Zinc...

Published: 11/24/2025 | Inventor(s): Christopher Rhodes, Samuel Kimmel, Ryan DeBlock, Debra Rosilon

Keywords(s): Batteries, Electrodes, Three-Dimensional Architectures

Category(s): Engineering, Chemistry, Materials

Treatment Method for Imparting Self-Healing And Shape Memory Properties To Certain CBDO Copolymers

Description: This technology involves a novel approach to treating amorphous CBDO (cyclobutanediol) copolymers, enabling them to exhibit self-healing and shape memory properties. By heating the copolymer above its glass transition temperature, the material undergoes a transformation that bestows it with these advanced functionalities. The copolymer...

Published: 11/11/2025 | Inventor(s): Gary Beall, Jesse Hancock, Chad Booth

Keywords(s): CBDO, Chemistry, Depositing and Regrowing Materials

Category(s): Chemistry, Materials

Durable Ceramic Nanocomposite Thermal Barrier Coatings for Metals And Refractories

Description: The technology centers around a unique coating composition comprising a polysilazane resin base, enhanced with various additives such as aluminum silicate nanotubes and ceramic microspheres. This composition, when applied and cured on substrates, forms a ceramic layer that exhibits superior thermal management and durability characteristics....

Published: 11/11/2025 | Inventor(s): Clois Powell, Ray Cook, Robert Habingreither, John Massingill

Keywords(s): Abrasion Resistance, Ceramic Coating Composition, Chemistry, Thermal Conductivity

Category(s): Engineering, Chemistry, Materials

Photoactivatable Cancer Prodrug Photoactivatable Ruthenium Compounds for Cancer Treatment

Description: This technology introduces a new class of photoactivatable compounds based on ruthenium for the treatment of cancer. Leveraging the principles of photodynamic therapy (PDT), these compounds are designed to be activated by light to target and disrupt cancer cells selectively, while sparing healthy tissues. This innovative approach aims...

Published: 11/18/2025 | Inventor(s): Alexander Kornienko, Tania Betancourt, Shuster Bonnet, Vincent van Rixel

Keywords(s): Cancer Treatment, Photoactivatable Ruthenium Compounds, Photodynamic Therapy Photodynamic Therapy

Category(s): Cancer, Chemistry, Life Science

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