Search Results - cancer

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Sphaeropsidin derivatives to combat aggressive cancers

Description: This technology involves the synthesis of new compounds based on the sphaeropsidin A structure, aimed at improving its potency against drug-resistant cancers. Utilizing a cross-metathesis reaction, these compounds have shown significant growth inhibitory activity in various human cancer cell lines, including glioblastoma, non-small cell...

Published: 4/14/2025 | Inventor(s): Alexander Kornienko, Dino Berthold, Antonio Evidente, Sachin Wagh, Willem van Otterlo, Aude Ingels, Veronique Mathieu

Keywords(s): Apoptosis, Cancer, Drug Resistance, Natural Products, Sphaeropsidin

Category(s): Cancer, Chemistry

Novel truncated miRNA-506-3p analogs for Neuroblastoma differentiation therapy

Description: Our research has developed a series of shortened miR-506-3p analogs designed to maintain strong differentiation-inducing activities comparable to the wildtype miR-506-3p. These analogs have been tested for their ability to induce neurite outgrowth and cell growth arrest in neuroblastoma cells, demonstrating significant potential for therapeutic...

Published: 4/14/2025 | Inventor(s): Liqin Du, Nakya Mesa-Diaz, Mitchell Smith

Keywords(s): Childhood Cancer, Differentiation Therapy, Differentiation-Inducing Agent, MicroRNA, miR-506-3p, Neuroblastoma, Shortened miRNA, Truncated Analog, Wildtype (WT)

Category(s): Life Science, Cancer

Photoactivatable Cancer Prodrug Photoactivatable Ruthenium Compounds for Cancer Treatment

Description: This technology introduces a new class of photoactivatable compounds based on ruthenium for the treatment of cancer. Leveraging the principles of photodynamic therapy (PDT), these compounds are designed to be activated by light to target and disrupt cancer cells selectively, while sparing healthy tissues. This innovative approach aims...

Published: 4/14/2025 | Inventor(s): Alexander Kornienko, Tania Betancourt, Shuster Bonnet, Vincent van Rixel

Keywords(s): Cancer Treatment, Photoactivatable Ruthenium Compounds, Photodynamic Therapy Photodynamic Therapy

Category(s): Cancer, Chemistry, Life Science